In general, samples should be considered an immutable resource, but how they are shared may be updated by changing their visibility and project properties and the tags associated with them may also be changed. All other sample attributes are read-only, and the associated metadata record should be used for storing additional (mutable) structured information about a sample.
Additional authorization checks: Note that PATCHing to update the sample's visibility triggers additional account- and organization-level checks. For certain accounts (e.g., those in which PII is deposited), it may not be possible to make samples shared or public. Please contact us to discuss setting additional restrictions on sample-sharing for your or your organization's account. Similarly, users may only add their samples to projects for which they have appropriate project-level permissions.